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However, a recent report demonstrated a non-apoptotic function of Bax in long-term depression of synaptic transmission with caspase-3 activation and Bax modulation as pivotal elements during synaptic plasticity [45]

Future studies should explore the role of iron metabolism in regulatory cells, such as regulatory innate lymphoid cells (ILCregs), Treg cells and Tr-1 cells as these are important in the regulation of an overzealous immune response and autoimmunity